THE ANTICANDIDAL PROPERTIES OF CHLORINATED 8-QUINOLINOLS

The in vitro anticandidal properties of six chlorinated 8-quinolinols (3-chloro-, 5-chloro-, 6-chloro-, 7-chloro-, 3,6-dichloro-, and 5,7-di chloro-8-quinolinols) were evaluated. Various concentrations of these compounds were added to cultures of Candida albicans and C. tropicalis grown in Sabouraud dextrose broth with and without bovine serum. The 5-chloro- and 6-chloro-8-quinolinols proved to be most effective at in hibiting the growth of C. albicans while 3,6-dichloro-8-quinolinol was most effective at controlling the growth of C. tropicalis. Cytotoxici ty tests on baby hamster kidney (BHK) cells, however, demonstrated tha t the compounds tested were cytotoxic at their minimum inhibitory conc entrations except for 3,6-dichloro-8-quinolinol which proved effective at inhibiting the growth of C. tropicalis at about one half the cytot oxic dose. Because this compound showed antifungal properties at conce ntrations that do not suppress mammalian cell growth, it merits furthe r investigation as a possible topical or systemic anticandidal agent.