POTENTIAL ANTIMALARIALS .22. SOME 2,4-DIAMINO-5-(3-TRIFLUOROMETHYLPHENYL)PYRIMIDINES AND 2,4-DIAMINO-5-(4-TRIFLUOROMETHYLPHENYL)PYRIMIDINESAND ,4-DIAMINO-5-(3,4-METHYLENEDIOXYPHENYL)PYRIMIDINES

A series of 10 pyrimethamine analogues containing 3'- and 4'-trifluoro methyl and 3/,4'-methylenedioxy groups has been prepared and tested fo r in vitro antimalarial activity against the FC-27 and kappa-1 isolate s of Plasmodium falciparum. Several of these compounds were almost as active as pyrimethamine against the drug-sensitive FC-27 isolate, and like pyrimethamine, they were much less active against the drug-resist ant kappa-1 isolate. The 4'-trifluoromethyl compunds, however, showed much smaller differences.