PATELLINS 1-6 AND TRUNKAMIDE-A - NOVEL CYCLIC HEXA-PEPTIDES, HEPTA-PEPTIDES AND OCTA-PEPTIDES FROM COLONIAL ASCIDIANS, LISSOCLINUM SP

Patellins 1-5 have been isolated from the colonial ascidian Lissoclinu m patella from Viti Levu, Fiji. Patellins 1 and 2 are cyclic hexapepti des, while patellins 3-5 are cyclic octapeptides. Two of these peptide s (patellins 3 and 5), a new cyclic octapeptide (patellin 6), a new cy clic heptapeptide (trunkamide A), and the known metabolite lissoclinol ide have also been isolated from a Lissoclinum sp. collected on the Gr eat Barrier Reef, Australia. All structures were determined by high-fi eld n.m.r. and mass spectroscopic methods, and by h.p.l.c. analysis of the constituent amino acids after hydrolysis of the peptides and deri vatization according to Marfey's procedure.