Js. Vaidya et al., MULTICENTRICITY OF BREAST-CANCER - WHOLE-ORGAN ANALYSIS AND CLINICAL IMPLICATIONS, British Journal of Cancer, 74(5), 1996, pp. 820-824
We studied the spatial relationship within the breast between multicen
tric foci (MCF) and the primary tumour in 30 modified radical mastecto
my specimens using Egan's correlated pathological-radiological method
using 5 mm slices of the whole breast. The relative positions within t
he breast of the primary tumour and MCF were used to calculate the rel
ative distribution of primary tumour rind MCF in the four quadrants of
the breast and the per cent breast volume that would be required to b
e excised to include all MCF. Nineteen (63%) breast harboured MCF. The
relative distribution of primary tumour and MCF in the four breast qu
adrants was significantly different (P=0.034). MCF were present beyond
the index quadrant (25% of breast volume including the tumour) in as
many as 79% (15/19) of breasts that harboured MCF; and in half the cas
es (15/30) when all breast were considered. This is in variance with t
he suggestion put forward previously that MCF are contained within the
index quadrant in 90% of cases. Although the number of patients in th
e present series is small, the probability of our finding being due to
; play of chance is 1 in 1500. In a large series of breast conservatio
n studies >90% of early breast recurrences have been found to occur in
the index quadrant. Our finding, that in half the patients (15/30) MC
F are present in quadrants other than the index quadrant. suggests tha
t MCF do not give rise to early boast recurrence.