HYDROGENATION OF PYRROLE DERIVATIVES .1. HYDROGENATIONS OVER PALLADIUM

Authors
HEGEDUS L MATHE T TUNGLER A
Citation
L. Hegedus et al., HYDROGENATION OF PYRROLE DERIVATIVES .1. HYDROGENATIONS OVER PALLADIUM, Applied catalysis. A, General, 143(2), 1996, pp. 309-316
Citations number
15
Categorie Soggetti
Chemistry Physical","Environmental Sciences
Journal title
Applied catalysis. A, General → ACNP
ISSN journal
0926860X
Volume
143
Issue
2
Year of publication
1996
Pages
309 - 316
Database
ISI
SICI code
0926-860X(1996)143:2<309:HOPD.H>2.0.ZU;2-D
Abstract
The heterogeneous catalytic hydrogenation of 1-methyl-2-pyrrole ethano l resulted in 1-methyl-2-pyrrolidine ethanol, an important and valuabl e pharmaceutical intermediate. In non-acidic medium, with carbon suppo rted palladium catalyst, applying solvent mixtures and mild reaction c onditions (6 bar, 80 degrees C) high conversion and selectivity were o btained. This hydrogenation is part of a newly developed and industria lly feasible synthesis.