SYNTHESIS OF A NEW RUTHENIUM COMPLEX OF A MACROCYCLIC LIGAND CONTAINING 1,10-PHENANTHROLINE, AND ITS PHOTO-MEDIATED COVALENT BINDING TO DNA

Authors
HIRAI M SHINOZUKA K OGAWA S SAWAI H
Citation
M. Hirai et al., SYNTHESIS OF A NEW RUTHENIUM COMPLEX OF A MACROCYCLIC LIGAND CONTAINING 1,10-PHENANTHROLINE, AND ITS PHOTO-MEDIATED COVALENT BINDING TO DNA, Chemistry Letters, (12), 1996, pp. 1113-1114
Citations number
21
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
12
Year of publication
1996
Pages
1113 - 1114
Database
ISI
SICI code
0366-7022(1996):12<1113:SOANRC>2.0.ZU;2-K
Abstract
A ruthenium complex of a macrocyclic compound, consisting of two 1,10- phenanthroline molecules bridged by sulfur, was synthesized by templat e-directed macrocyclization on the ruthenium ion. The complex links to DNA by photo-mediated substitution of the coordinated chloro ion with the heterocyclic base of DNA and induces DNA cleavage.