C. Chen et al., NEUROTROPHIN-3 AND TRKC-IMMUNOREACTIVE NEURONS IN RAT DORSAL-ROOT GANGLIA CORRELATE BY DISTRIBUTION AND MORPHOLOGY, Neurochemical research, 21(7), 1996, pp. 809-814
Previous studies have shown that a subpopulation of large dorsal root
ganglion neurons contains neurotrophin-3 (NT3)-like immunoreactivity.
It is not known, however, whether these NT3 immunoreactive neurons als
o express the high affinity receptor for NT3, trkC. In the present stu
dy, the distribution and morphology of trkC immunoreactive neurons hav
e been correlated with those of NT3 immunoreactive neurons in the dors
al root ganglia. Size and segmental distributions of both antigens ind
icate that they are present in the same group of large sensory neurons
. Almost twice the number of these neurons are present in the cervical
and lumbar spinal ganglia than in the thoracic, Go-localization study
indicates that 94% of NT3 immunoreactive neurons express trkC. Our fi
ndings support the proposal that NT3 in these neurons is derived from
their peripheral tar ets rather than synthesized in situ.