A CONVENIENT ONE-POT SYNTHESIS OF CYSTINE-CONTAINING PEPTIDES FROM PROTECTED PEPTIDYL RESINS USING THE TRIMETHYLSILYL CHLORIDE DIMETHYL-SULFOXIDE TRIFLUOROACETIC-ACID SYSTEM

Authors
TAMAMURA H ISHIHARA T OTAKA A KOIDE T MIYOSHI K IBUKA T FUJII N
Citation
H. Tamamura et al., A CONVENIENT ONE-POT SYNTHESIS OF CYSTINE-CONTAINING PEPTIDES FROM PROTECTED PEPTIDYL RESINS USING THE TRIMETHYLSILYL CHLORIDE DIMETHYL-SULFOXIDE TRIFLUOROACETIC-ACID SYSTEM, Journal of the Chemical Society. Perkin transactions. I, (16), 1996, pp. 1911-1912
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
16
Year of publication
1996
Pages
1911 - 1912
Database
ISI
SICI code
0300-922X(1996):16<1911:ACOSOC>2.0.ZU;2-F
Abstract
Cystine-containing peptides are obtained in a one-pot manner by treatm ent of protected peptidyl resins with trimethylsilyl chloride (TMSCl)- dimethyl sulfoxide (DMSO)-trifluoroacetic acid (TFA), The TMSCl-DMSO-T FA system simultaneously cleaves peptides from the resins, with deprot ection of all side chain protecting groups and disulfide bond formatio n.