ARISUGACIN-A AND ARISUGACIN-B, NOVEL AND SELECTIVE ACETYLCHOLINESTERASE INHIBITORS FROM PENICILLIUM SP FO-4259 .2. STRUCTURE ELUCIDATION

Authors
KUNO F SHIOMI K OTOGURO K SUNAZUKA T OMURA S
Citation
F. Kuno et al., ARISUGACIN-A AND ARISUGACIN-B, NOVEL AND SELECTIVE ACETYLCHOLINESTERASE INHIBITORS FROM PENICILLIUM SP FO-4259 .2. STRUCTURE ELUCIDATION, Journal of antibiotics, 49(8), 1996, pp. 748-751
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
49
Issue
8
Year of publication
1996
Pages
748 - 751
Database
ISI
SICI code
0021-8820(1996)49:8<748:AAANAS>2.0.ZU;2-V
Abstract
The structures of new acetylcholinesterase inhibitors, arisugacins A a nd B, were elucidated by NMR study. Arisugacins have a aR,6aR,12aS,12b S)-4a,6,6a,12,12a,12b-hexahydro-4a, ihydroxy-4,4,6a,12b-tetramethyl-4H ,11H-naphtho[2,1 -b]pyrano[3,4-e]pyran-1,11(SH)-dione moiety in common and 3,4-dimethoxyphenyl or 4-methoxyphenyl residues are attached to C -9 of the moiety.