KANCHANAMYCINS, NEW POLYOL MACROLIDE ANTIBIOTICS PRODUCED BY STREPTOMYCES-OLIVACEUS TU-4018 .1. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL-ACTIVITIES

Authors
FIEDLER HP NEGA M PFEFFERLE C GROTH I KEMPTER C STEPHAN H METZGER JW
Citation
Hp. Fiedler et al., KANCHANAMYCINS, NEW POLYOL MACROLIDE ANTIBIOTICS PRODUCED BY STREPTOMYCES-OLIVACEUS TU-4018 .1. TAXONOMY, FERMENTATION, ISOLATION AND BIOLOGICAL-ACTIVITIES, Journal of antibiotics, 49(8), 1996, pp. 758-764
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
49
Issue
8
Year of publication
1996
Pages
758 - 764
Database
ISI
SICI code
0021-8820(1996)49:8<758:KNPMAP>2.0.ZU;2-D
Abstract
The kanchanamycins, a group of novel 36-membered polyol macrolide anti biotics were detected in the culture filtrate and mycelium of Streptom yces olivaceus Tu 4018 by HPLC-diode-array and HPLC-electrospray-mass- spectrometry screening. The compounds show antibacterial and antifunga l activities, and are especially effective against Pseudomonas fluores cens. Besides the kanchanamycin complex, strain Tu 4018 produces the 4 2-membered macrolactones, oasomycin A and desertomycin A, as well as t ryptophan-dehydrobutyrine diketopiperazine and daidzein.