EFFECT OF FERROUS ION ON MILDIOMYCIN PRODUCTION BY STREPTOVERTICILLIUM-RIMOFACIENS

Authors
KISHIMOTO K PARK YS OKABE M AKIYAMA SI
Citation
K. Kishimoto et al., EFFECT OF FERROUS ION ON MILDIOMYCIN PRODUCTION BY STREPTOVERTICILLIUM-RIMOFACIENS, Journal of antibiotics, 49(8), 1996, pp. 770-774
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
49
Issue
8
Year of publication
1996
Pages
770 - 774
Database
ISI
SICI code
0021-8820(1996)49:8<770:EOFIOM>2.0.ZU;2-Z
Abstract
A specific regulatory effect of ferrous ion on a biosynthesis of mildi omycin by Streptoverticillium rimofaciens was investigated. The minima l concentration of ferrous ion necessary for the maximal production of mildiomycin was about 8 mu g/ml. The physiological effects of ferrous ion on the mildiomycin production were examined in the media with and without the ferrous ion. Addition of ferrous ion to the culture mediu m increased both the mildiomycin production (10 times) and an assimila tion of ammonium-nitrogen, activities of peptidase and protease.