MICROBIOLOGICAL N-DEOXYGENATION AND C-OXYGENATION OF PIOGLITAZONE-N-OXIDE IN A SINGLE FERMENTATION

Authors
JOHNSON RA MARSHALL VP LI GP SIH JC CIALDELLA JI LIGGETT WF NIDY EG
Citation
Ra. Johnson et al., MICROBIOLOGICAL N-DEOXYGENATION AND C-OXYGENATION OF PIOGLITAZONE-N-OXIDE IN A SINGLE FERMENTATION, Journal of antibiotics, 49(8), 1996, pp. 788-793
Citations number
23
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
49
Issue
8
Year of publication
1996
Pages
788 - 793
Database
ISI
SICI code
0021-8820(1996)49:8<788:MNACOP>2.0.ZU;2-X
Abstract
Oxygenation of pioglitazone-N'-oxide by a microorganism isolated from soil was accompanied by N-deoxygenation to produce the pioglitazone me tabolites yl)-2-pyridyl]ethoxy]benzyl]-2,4-thiazolidinedione and 5-[4- [2-(5-acetyl-2-pyridyl)ethoxy] benzyl]-2,4-thiazolidinedione. The oxyg enating/deoxygenating organism has been characterized as Streptomyces hygroscopicus strain 02179 (UC 11099). The culture has been deposited with Agricultural Research Service, USDA, with accession number NRRL 1 8975.