YM-24074, A NEW PEPTIDE ANTIBIOTIC .2. STRUCTURAL ELUCIDATION

Authors
SATO T TAKEBAYASHI Y TOKUNAGA T OZASA T
Citation
T. Sato et al., YM-24074, A NEW PEPTIDE ANTIBIOTIC .2. STRUCTURAL ELUCIDATION, Journal of antibiotics, 49(8), 1996, pp. 811-814
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
49
Issue
8
Year of publication
1996
Pages
811 - 814
Database
ISI
SICI code
0021-8820(1996)49:8<811:YANPA.>2.0.ZU;2-G
Abstract
YM-24074 (formerly called YL-01869P) is a new antibiotic and type I co llagenase inhibitor. The structure of this compound was elucidated by spectroscopic analysis and confirmed by acid degradation to be N-(1''- acetyl-3''-methylbutyl)-2-[2'- [(N-hydroxycarbamoyl)methyl]heptanoyl]- hexahydropyridazine-3-carboxamide. The stereochemistry of two of thre e chiral centers was determined by degradation products to be 3S, 2'R.