DITERPENES AND SYNTHETIC DERIVATIVES FROM VIGUIERA ASPILLIOIDES WITH TRYPANOMICIDAL ACTIVITY

Authors
DACOSTA FB ALBUQUERQUE S VICHNEWSKI W
Citation
Fb. Dacosta et al., DITERPENES AND SYNTHETIC DERIVATIVES FROM VIGUIERA ASPILLIOIDES WITH TRYPANOMICIDAL ACTIVITY, Planta medica, 62(6), 1996, pp. 557-559
Citations number
13
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences","Chemistry Medicinal
Journal title
Planta medica → ACNP
ISSN journal
00320943
Volume
62
Issue
6
Year of publication
1996
Pages
557 - 559
Database
ISI
SICI code
0032-0943(1996)62:6<557:DASDFV>2.0.ZU;2-2
Abstract
The dichloromethane extract of the tuberous roots of Viguiera aspillio ides was tested in vitro against T. cruzi and then investigated in ord er to identify its active compounds, which were the known diterpenes ( -)-ent-kaur-16-en-19-oic acid, (-)-trachyloban-19-oic acid, and (-)-ka uran-16 alpha-ol. Synthetic derivatives of the acidic compounds were o btained and tested; one of them, (-)-kaur-16-en-19-ol, was also active . Their IC50 are given.