THE H-POINT STANDARD ADDITIONS METHOD WHEN THE MATRIX EFFECT IS ABSENT - APPLICATION TO THE DETERMINATION OF CERTAIN CEPHALOSPORINS AND THEIR ACID-INDUCED DEGRADATION PRODUCTS

Authors
CAMPINSFALCO P GALLOMARTINEZ L SEVILLANOCABEZA A BOSCHREIG F
Citation
P. Campinsfalco et al., THE H-POINT STANDARD ADDITIONS METHOD WHEN THE MATRIX EFFECT IS ABSENT - APPLICATION TO THE DETERMINATION OF CERTAIN CEPHALOSPORINS AND THEIR ACID-INDUCED DEGRADATION PRODUCTS, Analytical letters, 29(11), 1996, pp. 2039-2054
Citations number
26
Categorie Soggetti
Chemistry Analytical
Journal title
Analytical letters → ACNP
ISSN journal
00032719
Volume
29
Issue
11
Year of publication
1996
Pages
2039 - 2054
Database
ISI
SICI code
0003-2719(1996)29:11<2039:THSAMW>2.0.ZU;2-8
Abstract
This paper discusses the requirements and scope of application of the II-point Standard Additions Method (HPSAM) when the matrix effect is a bsent. It is demonstrated that the HPSAM calibration method works well with slopes of calibration graphs as standards. It is applied to the resolution of binary mixtures of intact and acid degraded cephalospori ns. The results obtained are better than those obtained by second deri vative spectrophotometry.