SYNTHESIS OF BETA-CYCLODEXTRIN DIMERS AS CARRIER SYSTEMS FOR PHOTODYNAMIC THERAPY OF CANCER

Authors
RUEBNER A MOSER JG KIRSCH D SPENGLER B ANDREES S ROEHRS S
Citation
A. Ruebner et al., SYNTHESIS OF BETA-CYCLODEXTRIN DIMERS AS CARRIER SYSTEMS FOR PHOTODYNAMIC THERAPY OF CANCER, Journal of inclusion phenomena and molecular recognition in chemistry, 25(1-3), 1996, pp. 35-38
Citations number
5
Categorie Soggetti
Chemistry,Crystallography
Journal title
Journal of inclusion phenomena and molecular recognition in chemistry → ACNP
ISSN journal
09230750
Volume
25
Issue
1-3
Year of publication
1996
Pages
35 - 38
Database
ISI
SICI code
0923-0750(1996)25:1-3<35:SOBDAC>2.0.ZU;2-W
Abstract
The aim of our investigation was the development of carrier systems fo r an application of inert drugs in polyphasic photodynamic tumor thera py. As carrier systems, beta-cyclodextrin dimers linked at their prima ry and secondary faces by spacers of varying lengths were synthesized. Cyclodextrins are known to form stable inclusion complexes with porph yrinoid photosensitizers. The influence of spacer length on the P-cycl odextrin dimer inclusion complexes with porphyrinoid photosensitizers was studied.