INFLUENCE OF DEGREE AND PATTERNS OF SUBSTITUTION ON THE INCLUSION PROPERTIES OF ETHYLATED BETA-CYCLODEXTRINS

Different batches of ethylated derivatives of beta-cyclodextrins (Et-b eta CD) obtained by various synthetic routes were used as host molecul es to prepare inclusion compounds of salbutamol. Previous results show ed that these complexes were suitable to achieve variable sustained-re lease behaviour of salbutamol. The mechanism of sustained-release was related to the inclusion capacity and physicochemical properties of Et -beta CD. Among the various analytical techniques carried out to chara cterize them, high resolution NMR afforded relevant information in ter ms of degree and patterns of subtitution, which could explain the diff erences observed between CD derivatives.