ENHANCED WATER-SOLUBILITY OF ALBENDAZOLE BY HYDROXYPROPYL-BETA-CYCLODEXTRIN COMPLEXATION

Authors
BASSANI VL KRIEGER D DUCHENE D WOUESSIDJEWE D
Citation
Vl. Bassani et al., ENHANCED WATER-SOLUBILITY OF ALBENDAZOLE BY HYDROXYPROPYL-BETA-CYCLODEXTRIN COMPLEXATION, Journal of inclusion phenomena and molecular recognition in chemistry, 25(1-3), 1996, pp. 149-152
Citations number
7
Categorie Soggetti
Chemistry,Crystallography
Journal title
Journal of inclusion phenomena and molecular recognition in chemistry → ACNP
ISSN journal
09230750
Volume
25
Issue
1-3
Year of publication
1996
Pages
149 - 152
Database
ISI
SICI code
0923-0750(1996)25:1-3<149:EWOABH>2.0.ZU;2-N
Abstract
The inclusion complexation of methyl(5-(propylthio)-1H- benzimidazol-2 -yl) carbamate, albendazole (ABZ) with 2-hydroxypropyl-beta-cyclodextr in (HP beta CD) in water was investigated with a view to improving the low aqueous solubility of the drug. The combination of albendazole an d HP beta CD in a molar ratio of 1/10 resulted in a significant increa se in the aqeous solublity of the drug, up to 3500 times. Albendazole/ HP beta CD complexes could be recommended as a parenterally administer ed formulation because of its good solubility properties and the safet y of the cyciodextrin used.