COMPLEXATION OF NEW ACTIVE ANTIBACTERIAL ADAMANTAN DERIVATIVES WITH BETA-CD - PREPARATION AND CHARACTERIZATION OF COMPLEXES - STUDY OF THE THERMOTROPIC PROPERTIES OF PURE AND COMPLEX FORM WITH DIPALMITOYL PHOSPHATIDYLCHOLINE BILAYERS

beta-Cyclodextrin (BCD) complexes of I1-8, I1-10, I1-12, were prepared , isolated and characterized in solid and liquid form. Their thermotro pic effects were studied by inserting them in DPPC bilayers both in pu re and complexed forms. The results have shown that the presence of I1 -8 causes spliting, broadening and lowering of the phase transition of DPPC bilayers. Their effects are more significant when I1-10 and I1-1 2 are inserted. These differential effects are eliminated when the abo ve studied three molecules are incorporated in a complex form with PCD in DPPC bilayers. The obtained results suggest that the bromine salts in the bilayer are likely to remain in the complex form rather than r eleased in the membrane.