THE APPLICATION OF EQUILIBRIUM DIALYSIS TO THE DETERMINATION OF DRUG-CYCLODEXTRIN STABILITY-CONSTANTS

Authors
UGWU SO ALCALA MJ BHARDWAJ R BLANCHARD J
Citation
So. Ugwu et al., THE APPLICATION OF EQUILIBRIUM DIALYSIS TO THE DETERMINATION OF DRUG-CYCLODEXTRIN STABILITY-CONSTANTS, Journal of inclusion phenomena and molecular recognition in chemistry, 25(1-3), 1996, pp. 173-176
Citations number
7
Categorie Soggetti
Chemistry,Crystallography
Journal title
Journal of inclusion phenomena and molecular recognition in chemistry → ACNP
ISSN journal
09230750
Volume
25
Issue
1-3
Year of publication
1996
Pages
173 - 176
Database
ISI
SICI code
0923-0750(1996)25:1-3<173:TAOEDT>2.0.ZU;2-L
Abstract
The equilibrium dialysis method was applied to the determination of dr ug-cyclodextrin stability constants using diflunisal and 2-hydroxyprop yl-beta-cyclodextrin (HPBCD) as a model system. Analysis of data showe d the existence of a linear Scatchard plot, which is indicative of the formation of a 1:1 diflunisal:HPBCD complex. The stoichiometry of the complex was verified using the appropriate mass action law equation. The complexation constant (K-c) was 3801 +/- 541 M(-1). The K-o obtain ed using the equilibrium dialysis method was comparable to that obtain ed using a potentiometric method (5564 +/- 56 M(-1)).