ADRENOLEUKODYSTROPHY INDICATED BY ABNORMAL ELECTRO-ENCEPHALOGRAPHY

An 8 year old boy with adrenoleukodystrophy and his asymptomatic broth er, both with abnormal electroencephalography as the initial sign of a drenoleukodystrophy, are reported. after suffering from aseptic mening itis caused by Echo virus 30, the first case was suspected of having a complication of meningitis because of persistent abnormal electro-enc ephalography (i.e. slow wave bursts in the occipital region). This pat ient was finally diagnosed as having adrenoleukodystrophy because of t he increased level of very long chain saturated fatty acids, and typic al occipital lesions demonstrated by magnetic resonance imaging and co mputed tomography. Dietary therapy was tried, but the course was progr essive. The brother's electroencephalography was also abnormal and so was diagnosed as having asymptomatic adrenoleukodystrophy because of a n increased level of very long chain saturated fatty acids, although b rain magnetic resonance imaging was normal. Abnormal electro-encephalo graphy can therefore be an initial sign of adrenoleukodystrophy even i f magnetic resonance imaging shows no abnormality in the brain.