The loss of a loved one is a potent and frequent life stressor for tho
se infected with HIV and those at risk for infection. Early in the epi
demic, bereavement in homosexual men was associated with increased dis
tress in a dose-response relationship with the number of losses. More
recent research suggests that this is not the case, though a relations
hip with increased grief level and with perceived self-threat is still
recognized. A change in the form of bereavement response to a reactio
n resembling chronic, post-traumatic distress is also possible. Future
research using a stressor-support-coping model is advocated to invest
igate this possibility. Studies on the effect of bereavement should be
conducted with other HIV infected and at-risk groups. Brief, supporti
ve, group psychotherapy for recent loss and total loss burden due to H
IV/AIDS is advocated to prevent associated psychological morbidity. Th
e effects of such interventions on immune measures and the clinical pr
ogression of HIV disease also merits investigation.