THE USE OF A SYNTHETIC PROSTAGLANDIN E(1) ANALOG AS A GASTRIC PROTECTANT AGAINST ASPIRIN-INDUCED HEMORRHAGE IN THE DOG

Authors
BOWERSOX TS LIPOWITZ AJ HARDY RM JOHNSTON GR HAYDEN DW SCHWARTZ S KING VL
Citation
Ts. Bowersox et al., THE USE OF A SYNTHETIC PROSTAGLANDIN E(1) ANALOG AS A GASTRIC PROTECTANT AGAINST ASPIRIN-INDUCED HEMORRHAGE IN THE DOG, The Journal of the American Animal Hospital Association, 32(5), 1996, pp. 401-407
Citations number
30
Categorie Soggetti
Veterinary Sciences
Journal title
The Journal of the American Animal Hospital Association → ACNP
ISSN journal
05872871
Volume
32
Issue
5
Year of publication
1996
Pages
401 - 407
Database
ISI
SICI code
0587-2871(1996)32:5<401:TUOASP>2.0.ZU;2-3
Abstract
Misoprostol prevented gastric hemorrhage in dogs, each of which receiv ed aspirin (35 mg/kg body weight, orally q 8 hrs for 10 days), All dog s receiving aspirin alone had gastroscopic and histopathological lesio ns, No lesions were noted in four of five dogs given aspirin plus miso prostol (15 mu g/kg body weight, q 8 hrs for five days; then 7.5 mu g/ kg body weight, q 8 hrs for five days), Four of 10 dogs receiving 15 m u g/kg body weight of misoprostol developed diarrhea, The misoprostol dose was reduced to 7.5 mu g/kg body weight, and the diarrhea subsided .