MONTE-CARLO RESULTS FOR THE 3-POLY TEST FOR ANIMAL CARCINOGENICITY EXPERIMENTS

Authors
TAN WY ZHANG JH
Citation
Wy. Tan et Jh. Zhang, MONTE-CARLO RESULTS FOR THE 3-POLY TEST FOR ANIMAL CARCINOGENICITY EXPERIMENTS, Environmental health perspectives, 104(8), 1996, pp. 872-877
Citations number
11
Categorie Soggetti
Public, Environmental & Occupation Heath","Environmental Sciences
Journal title
Environmental health perspectives → ACNP
ISSN journal
00916765
Volume
104
Issue
8
Year of publication
1996
Pages
872 - 877
Database
ISI
SICI code
0091-6765(1996)104:8<872:MRFT3T>2.0.ZU;2-E
Abstract
By using a two stage model of carcinogenesis, we generated Monte Carlo studies to assess the efficiency and robustness of the 3-poly test fo r animal carcinogenicity experiments. The Monte Carlo results indicate that the 3-poly test is quite powerful for detecting the carcinogenic effects of complete carcinogens, moderate promoters, and initiators w ith moderate or large effect, but, in some cases, it is less powerful for weak initiators or weak promoters. As expected, the 3-poly test is insensitive to the toxicity of many agents.