PROPHYLACTIC USE OF SODIUM-SULFATE AND THIAMINE HYDROCHLORIDE IN EXPERIMENTAL LEAD-POISONING IN CALVES

Efficacy of sodium sulphate and thiamine was studied in experimental l ead poisoning in calves given lead acetate orally @ 10 mg/kg body weig ht for the first 30 days and 15 mg/kg/day for further 33 days alone (g roup B) or in combination with sodium sulphate @, 7.5 mg/kg/day orally (group C) or with thiamine hydrochloride @ 5 mg/kg/day subcutaneously (group D). All calves developed signs of lead toxicity, but the onset of signs was delayed and mortality rate was lower ill calves of group s C and D than those of group D. Increased lead concentration In blood and tissue was recorded in calves of groups B, C and D. The lead conc entration was comparatively higher in group B. than C and D. On the ba sis of the severity of clinical signs; mortality pattern, haematobioch emical changes and blood and tissue lead concentration; it was conclud ed that thiamine is more effective in preventing toxic effects of lead than sodium sulphate.