THE EFFECTS OF 2-CHLOROADENOSINE AND DEOXYCOFORMYCIN ON THE ATP LEVEL, NA-K ATPASE ACTIVITY IN EXPERIMENTAL BRAIN ISCHEMIA OF GERBIL

The effect of 2-chloroadenosine, stable adenosine analog, and deoxycof ormycin, adenosine deaminase inhibitor on brain ATP level and Na-K ATP ase activity in ischemia were studied. The brain ATP level was increas ed after we administered both 2-chloroadenosine and deoxycoformycin, b ut Na-K ATPase activity did not change after deoxycoformycin. The resu lts suggest that 2-chloroadenosine treatment influenced both the ATP p roduction and membrane permeability due to cerebral ischemia. Deoxycof ormycin did not protect the membrane permeability, although it increas ed the ATP production.