KINETIC RESOLUTION OF RACEMIC ALPHA-HYDROXY KETONES BY LIPASE-CATALYZED IRREVERSIBLE TRANSESTERIFICATION

Authors
ADAM W DIAZ MT FELL RT SAHAMOLLER CR
Citation
W. Adam et al., KINETIC RESOLUTION OF RACEMIC ALPHA-HYDROXY KETONES BY LIPASE-CATALYZED IRREVERSIBLE TRANSESTERIFICATION, Tetrahedron : asymmetry, 7(8), 1996, pp. 2207-2210
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
7
Issue
8
Year of publication
1996
Pages
2207 - 2210
Database
ISI
SICI code
0957-4166(1996)7:8<2207:KRORAK>2.0.ZU;2-O
Abstract
Asymmetric acetylation of racemic a-hydroxy ketones with isopropenyl a cetate catalyzed by lipases afforded the optically active keto alcohol s and acetates in high enantiomeric excess (up to 99%); an enzymatic k inetic resolution which may be performed on preparative scale. Copyrig ht (C) 1996 Elsevier Science Ltd