AN EFFICIENT SYNTHESIS OF (3R)-4-AMINO-3-HYDROXY BUTYRIC-ACID (GABOB)VIA CYCLIC SULFITE METHODOLOGY

Authors
LOHRAY BB REDDY AS BHUSHAN V
Citation
Bb. Lohray et al., AN EFFICIENT SYNTHESIS OF (3R)-4-AMINO-3-HYDROXY BUTYRIC-ACID (GABOB)VIA CYCLIC SULFITE METHODOLOGY, Tetrahedron : asymmetry, 7(8), 1996, pp. 2411-2416
Citations number
47
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
7
Issue
8
Year of publication
1996
Pages
2411 - 2416
Database
ISI
SICI code
0957-4166(1996)7:8<2411:AESO(B>2.0.ZU;2-6
Abstract
The cyclic sulfite 6 prepared from enantiomerically pure N-[(2S)-2,3-d ihydroxypropan-1-yl]phthalimide 2 derived from D-mannitol upon treatme nt with KCN in DMF afforded N-[(2S)-3-cyano-2-hydroxy propan-1-yl]phth alimide which was hydrolysed to furnish good yield of GABOB. Copyright (C) 1996 Elsevier Science Ltd