M. Navasa et al., QUALITY-OF-LIFE, MAJOR MEDICAL COMPLICATIONS AND HOSPITAL-SERVICE UTILIZATION IN PATIENTS WITH PRIMARY BILIARY-CIRRHOSIS AFTER LIVER-TRANSPLANTATION, Journal of hepatology, 25(2), 1996, pp. 129-134
Aims/Methods: Major medical complications, hospital service utilizatio
n and quality of life were investigated in 26 out of 29 consecutive pr
imary biliary cirrhosis transplanted patients who survived at least 2
years after the procedure (90% survival rate). Results: Before liver t
ransplant, the most relevant clinical data were jaundice (96%), prurit
us (92%), ascites (50%), gastrointestinal bleeding (19%), hepatic ence
phalopathy (12%) and bone pain (12%), During the first postoperative y
ear, the most significant complications were bone pain (58%) and fract
ures (31%), arterial hypertension (50%), and mild/moderate renal failu
re (46%), The frequency of these complications remained similar during
the second year, but there was a significant reduction in the inciden
ce of bone fractures, Bone pain was the only postoperative complicatio
n which correlated with an increased number of unscheduled outpatient
and emergency visits, Quality of life was measured cross-sectionally e
ither at or after the second postoperative year, The Karnofsky index w
as 90 in 69% of the patients and 76% were able to perform usual daily
activities, Self-assessed health perception was good or very good in a
lmost all the patients. However, the Nottingham Health Profile showed
that approximately 70% of the patients gave a positive response to som
e questions in areas of pain, sleep, emotional reactions and physical
activities. Conclusions: The results of the present study confirm that
patients with primary biliary cirrhosis have a high survival rate aft
er liver transplantation and that bone pain and fractures are importan
t postoperative complications, Good self-perceived health and return t
o daily activities evidenced in most PBC patients should be balanced w
ith problems identified by more specific tools, which could have an im
pact in the health service utilization and quality of life.