STRUCTURAL MOTIFS OF THE DIMERIC LEWIS GLYCOLIPIDS AS DETERMINED BY NMR-SPECTROSCOPY AND MOLECULAR-DYNAMICS SIMULATIONS

Citation
A. Geyer et al., STRUCTURAL MOTIFS OF THE DIMERIC LEWIS GLYCOLIPIDS AS DETERMINED BY NMR-SPECTROSCOPY AND MOLECULAR-DYNAMICS SIMULATIONS, Chemistry, 2(8), 1996, pp. 981-988
Citations number
56
Categorie Soggetti
Chemistry
Journal title
ISSN journal
09476539
Volume
2
Issue
8
Year of publication
1996
Pages
981 - 988
Database
ISI
SICI code
0947-6539(1996)2:8<981:SMOTDL>2.0.ZU;2-P
Abstract
Several monomeric and dimeric Lewis glycolipids have been investigated by NMR spectroscopy, and structural aspects were modelled by computer . From the pseudo-C-2-symmetric tetrasaccharide unit that forms the re cognition domain of the Lewis Y and Lewis b antigens, a totally C-2-sy mmetric tetrasaccharide was designed that contains the structural elem ent common to all Lewis antigens. Finally, a model for the presentatio n of dimeric Lewis antigens at membrane surfaces was derived. The over all shapes of the dimeric Lewis oligosaccharides are defined by the co nnectivity of the sugar residues within rigid tri- and tetrasaccharide building blocks.