The perioperative use of antibiotics is an established and accepted te
chnique for the prevention of postoperative infection. Intravenous adm
inistration often is preferred, and intramuscular administration is po
ssible, although it has certain drawbacks. This article examines a var
iety of other routes of administration for delivering antibiotics loca
lly to the surgical site. These techniques merit further study in pros
pectively randomized trials.