ACEBUTOLOL OVERDOSE TREATED WITH HEMODIALYSIS AND EXTRACORPOREAL MEMBRANE-OXYGENATION

Authors
ROONEY M MASSEY KL JAMALI F ROSIN M THOMSON D JOHNSON DH
Citation
M. Rooney et al., ACEBUTOLOL OVERDOSE TREATED WITH HEMODIALYSIS AND EXTRACORPOREAL MEMBRANE-OXYGENATION, Journal of clinical pharmacology, 36(8), 1996, pp. 760-763
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of clinical pharmacology → ACNP
ISSN journal
00912700
Volume
36
Issue
8
Year of publication
1996
Pages
760 - 763
Database
ISI
SICI code
0091-2700(1996)36:8<760:AOTWHA>2.0.ZU;2-G
Abstract
A case involving a 27-year-old woman who ingested an overdose of acebu tolol is presented. Extracorporeal membrane oxygenation was initiated to stabilize the patient's condition before commencing hemodialysis. S -diacetolol (the N-acetelation product of acebutolol) was cleared with hemodialysis. It is suggested that extracorporeal membrane oxygenatio n may be of short-term benefit in the treatment of overdoses with beta -adrenergic agents such as acebutolol when accelerated clearance with hemodialysis is anticipated.