We report an initial laser Doppler perfusion study of the eyelids and
compare the results with those of other cutaneous regions. Eleven heal
thy subjects with no prior medical or surgical history, or eyelid malp
osition underwent laser Doppler perfusion scanning of six skin locatio
ns: right forearm, right middle fingertip, right upper eyelid, right l
ower eyelid, left upper eyelid, and left lower eyelid. Cutaneous perfu
sion in the four eyelid locations and right middle fingertip were stat
istically similar to each other but significantly higher than that in
the right forearm (p = 0.002). Also, mean perfusion in pretarsal skin
was >50% than that in preseptal skin (p = 0.002). In addition, in an e
yelid with histopathologically documented basal cell carcinoma, cutane
ous perfusion was significantly higher than the mean of the normal eye
lids (p = 0.002). Eyelids are perfused at the same high rate as are ot
her regions of the head, and significantly higher than low flow region
s, such as the extremities. Future application of this laser Doppler p
erfusion scanning include assessing burn depth, postoperative monitori
ng of periorbital tissue transfer, distinguishing benign and malignant
adnexal skin lesions, and establishing the pathologic margins of lid
tumors.