THE NEUROTENSIN RECEPTOR ANTAGONIST SR-48692, DECREASES EXTRACELLULARSTRIATAL GABA IN RATS

Authors
CHAPMAN MA SEE RE
Citation
Ma. Chapman et Re. See, THE NEUROTENSIN RECEPTOR ANTAGONIST SR-48692, DECREASES EXTRACELLULARSTRIATAL GABA IN RATS, Brain research, 729(1), 1996, pp. 124-126
Citations number
18
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
729
Issue
1
Year of publication
1996
Pages
124 - 126
Database
ISI
SICI code
0006-8993(1996)729:1<124:TNRASD>2.0.ZU;2-3
Abstract
Intracranial microdialysis was utilized to assess the effects of the n ovel neurotensin antagonist SR 48692 on extracellular gamma-amino-buty ric acid (GABA) and glycine in the striatum. Subcutaneous injection of SR 48692 (0.2 mg/kg) significantly decreased extracellular striatal G ABA levels, with peak decreases occurring 2-3 h post-injection. Inject ion of SR 48692 had no significant effect on glycine levels. These dat a suggest that endogenous neurotensin may modulate striatal GABA level s.