FORMULATION AND CLINICAL-EVALUATION OF A HYDROCORTISONE SOLUTION FOR THE TREATMENT OF ORAL-DISEASE

The purpose of this study was the formulation and clinical evaluation of a steroid solution for the treatment of oral disease. The steroid u sed for this work was hydrocortisone and its solubility was increased by complex formation with 2-hydroxypropyl-beta-cyclodextrin. In a clin ical efficacy study of the hydrocortisone solution in 50 patients, the re were no reports of ill effects and no side effects such as erythema or superinfection were noticed. Of those treated, 78% showed improvem ent, with 48% showing considerable clinical improvement. The prelimina ry clinical observations show that this hydrocortisone solution was ea sy to use, had a clinical efficacy that compares well with much more p otent preparations and thus should help to minimise the prevalence of harmful side effects of the treatment of these distressing conditions.