EFFECT OF 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN ON THE AQUEOUS SOLUBILITYOF THE ANESTHETIC AGENT PROPOFOL (2,6-DIISOPROPYLPHENOL)

Authors
TRAPANI G LOPEDOTA A FRANCO M LATROFA A LISO G
Citation
G. Trapani et al., EFFECT OF 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN ON THE AQUEOUS SOLUBILITYOF THE ANESTHETIC AGENT PROPOFOL (2,6-DIISOPROPYLPHENOL), International journal of pharmaceutics, 139(1-2), 1996, pp. 215-218
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
139
Issue
1-2
Year of publication
1996
Pages
215 - 218
Database
ISI
SICI code
0378-5173(1996)139:1-2<215:EO2OTA>2.0.ZU;2-E
Abstract
The inclusion complexation of Propofol (2,6-diisopropylphenol), an int ravenous anaesthetic agent in clinical use, with 2-hydroxypropyl-beta- cyclodextrin (HP beta CyD) was investigated for the purpose of improvi ng the low aqueous solubility and developing a potentially acceptable aqueous formulation. The aqueous solubility of propofol was increased as a function of HP beta CyD concentration affording a linear phase-so lubility profile.