COMPATIBILITY AND STABILITY OF VANCOMYCIN HYDROCHLORIDE WITH PVC INFUSION MATERIAL IN VARIOUS CONDITIONS USING STABILITY-INDICATING HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC ASSAY

The stability and compatibility of vancomycin hydrochloride injection in various diluents with polyvinyl chloride (PVC) containers were stud ied under different conditions of temperature and light. Drug was dilu ted to 5 mg/ml and 8 mg/ml in injection solutions for 1 and 24 h-simul ated infusions. Vancomycin hydrochloride injection was also prepared t o 5 mg/ml in PVC bags and stored at 4 degrees C over 7 days with prote ction from light and at 22 degrees C over 48 h without protection from light. Physical compatibility with PVC and chemical stability in solu tion of vancomycin were assessed by visual examination and by measurin g the concentration of drug in duplicate with stability-indicating hig h-performance chromatographic assay. There were no visual change, no c olor change, no visible precipitation and no loss of the drug. When ad mired in 0.9% sodium chloride injection or 5% dextrose injection, vanc omycin hydrochloride 5 and 8 mg/ml was compatible and stable for 1 and 24 h, respectively, of simulated infusion using PVC bags through PVC administration sets without protection from light. On the other hand, in the same diluents, vancomycin hydrochloride 5 mg/ml was compatible and stable with PVC bags for at least 48 h at 22 degrees C without pro tection from light and for at least 7 days at 4 degrees C with protect ion from light.