Objective: To determine the uptake of medical interventions amongst wo
men known to be HIV positive and in contact with service providers. Su
bjects: 400 HIV positive women from 15 STD/HIV clinics in Britain and
Ireland recruited to the MRC collaborative study of HIV infection in w
omen between June 1992 and August 1994. Methods: Data obtained prospec
tively through direct questioning of all women by a physician or resea
rch nurse and review of medical and laboratory records. Data recorded
on standardised forms and analysed centrally. Results: Nearly one quar
ter (24%) of women with an AIDS diagnosis had never received Pneumocys
tis carinii pneumonia prophylaxis, and 24% had never received any anti
retroviral therapy. Fewer than two-thirds of black African women had h
ad a chest radiograph. Only one woman had received Pneumovax and only
4% of women had ever taken part in a clinical trial. Conclusions: A su
bstantial proportion of women with HIV infection did not receive inter
ventions of proven benefit, and participation in clinical trials was v
ery uncommon. The reasons for such poor uptake should be explored amon
g both health care workers and women with HIV infection.