MODIFIED SPECTROPHOTOMETRIC METHOD FOR THE DETERMINATION OF SOME IMPORTANT ANTIBIOTICS THROUGH CHARGE-TRANSFER COMPLEXATION REACTION WITH CHLORANIL

A new modified spectrophotometric procedures are presented for the det ermination of three pharmaceutical antibiotic compounds through chage- transfere complexation reaction with chloranil. The complex shows an a bsorption mAxima at 550 nm, having a molar absorptivity coefficient of 5.55x10(3),7.81x10(3) and 1.38x10(4) 1. mol(-1)cm(-1) for ampicillin, amoxycillin and neomycin, respectively. Optimization of the reaction conditions has been investigated. Obediance to Beer's law (40 mu g/ml) permitted the assay of thes drugs in its dosage forms. A variety of p harmaceutical dosage forms containing ampicillin, amoxycillin and neom ycin are successfully analysed by tile proposed procedure.