DIASTEREOSELECTIVE ADDITION OF GRIGNARD-REAGENTS TO AZETIDINE-2,3-DIONE - SYNTHESIS OF NOVEL TAXOL(R) ANALOGS

Authors
KANT J SCHWARTZ WS FAIRCHILD C GAO Q HUANG S LONG BH KADOW JF LANGLEY DR FARINA V VYAS D
Citation
J. Kant et al., DIASTEREOSELECTIVE ADDITION OF GRIGNARD-REAGENTS TO AZETIDINE-2,3-DIONE - SYNTHESIS OF NOVEL TAXOL(R) ANALOGS, Tetrahedron letters, 37(36), 1996, pp. 6495-6498
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
36
Year of publication
1996
Pages
6495 - 6498
Database
ISI
SICI code
0040-4039(1996)37:36<6495:DAOGTA>2.0.ZU;2-5
Abstract
Synthesis and cytotoxicity properties of novel C-2' analogues of pacli taxel are described. The analogues were synthesized using Holton's bet a-lactam approach to append the side chain on baccatin III. The key in termediate to the synthesis of novel analogues was prepared employing an unprecedented stereocontrolled addition of Grignard reagent to a ch iral azetidine-2,3-dione. Copyright (C) 1996 Elsevier Science Ltd