CANDIDA-RUGOSA LIPASE - ENANTIOSELECTIVITY ENHANCEMENTS IN ORGANIC-SOLVENTS

Authors
PERSICHETTI RA LALONDE JJ GOVARDHAN CP KHALAF NK MARGOLIN AL
Citation
Ra. Persichetti et al., CANDIDA-RUGOSA LIPASE - ENANTIOSELECTIVITY ENHANCEMENTS IN ORGANIC-SOLVENTS, Tetrahedron letters, 37(36), 1996, pp. 6507-6510
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
36
Year of publication
1996
Pages
6507 - 6510
Database
ISI
SICI code
0040-4039(1996)37:36<6507:CL-EEI>2.0.ZU;2-J
Abstract
Chiral resolutions of carboxylic acids (1-3) and alcohol (4) were carr ied out through esterification or transesterification in organic solve nts using cross-linked enzyme crystals (CLEC(R)) of Candida rugosa lip ase (CRL). Comparison of these results with those of elude CRL reveal significant differences. As was seen in resolution through hydrolysis, (1) a marked improvement in enantioselectivity is realized with the CL EC. Additionally, the stability afforded the enzyme in CLEC form leads to a higher activity in organic solvent. Copyright (C) 1996 Elsevier Science Ltd