SYNTHESIS AND REACTIVITY OF A TRANSITION METAL-CARBONYL IMIDOESTER DESIGNED FOR THE SELECTIVE AND COVALENT LABELING OF BIOLOGICAL MACROMOLECULES

Authors
BLANALT S SALMAIN M MALEZIEUX B JAOUEN G
Citation
S. Blanalt et al., SYNTHESIS AND REACTIVITY OF A TRANSITION METAL-CARBONYL IMIDOESTER DESIGNED FOR THE SELECTIVE AND COVALENT LABELING OF BIOLOGICAL MACROMOLECULES, Tetrahedron letters, 37(36), 1996, pp. 6561-6564
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
36
Year of publication
1996
Pages
6561 - 6564
Database
ISI
SICI code
0040-4039(1996)37:36<6561:SAROAT>2.0.ZU;2-B
Abstract
The first transition metal-carbonyl water-soluble imidoester has been prepared in several steps and characterised by classical spectroscopic methods. It is aimed at the selective conjugation of amine-containing biomolecules such as proteins in aqueous medium,leading to conjugates that retain their net charge. A preliminary reactivity study with bov ine serum albumin (BSA) is reported. Copyright (C) 1996 Published by E lsevier Science Ltd