THE FIRST EXPERIMENTAL-EVIDENCE OF DIFFERENTIAL HYDRATION OF E Z ISOMERS OF STERICALLY HINDERED AMIDES - ONE-DIMENSIONAL STEADY-STATE SELECTIVE INTERMOLECULAR C-13, H-1 OVERHAUSER EFFECT STUDY OF TERT-BUTYLFORMAMIDE/

One dimensional steady-state selective intermolecular C-13, H-1 Overha user effect study of tert-butylformamide provides the first experiment al evidence of differentical hydration of the Z isomer, compared to th e E isomer, due to the presence of the bulky tert-butyl group; the sig nificant decrease in the population of the Z isomer should be attribut ed to steric effects and deformation of the amide bond with hydration differences playing a significant role. Copyright (C) 1996 Elsevier Sc ience Ltd