VERRUCOUS CARCINOMA OF THE RENAL PELVIS - CASE PRESENTATION AND REVIEW OF THE LITERATURE

Squamous cell carcinoma (SCC) of the renal pelvis is an uncommon tumou r that has occasionally been associated with horseshoe kidney. The ver rucous form of well-differentiated SCC has not been described previous ly at this site. We describe such a tumour in a 41-year-old man, who p resented with gross haematuria and recurrent pyelonephritis caused by staghorn calculi within a horseshoe kidney. Histology showed extensive keratinising squamous metaplasia of the pelvic urothelium with an are a of verrucous acanthosis and underlying invasion of the pelvic smooth muscle by broad tongues of squamous epithelium without atypia, Local lymph nodes were not involved by tumour, Immunohistochemistry and poly merase chain reaction revealed no evidence of human papillomavirus inf ection. The literature regarding verrucous carcinoma of the urothelial tract is reviewed.