CHARACTERIZATION OF AN INHIBITOR-RESISTANT ENZYME IRT-2 DERIVED FROM TEM-2 BETA-LACTAMASE PRODUCED BY PROTEUS-MIRABILIS STRAINS

Authors
BRET L CHANAL C SIROT D LABIA R SIROT J
Citation
L. Bret et al., CHARACTERIZATION OF AN INHIBITOR-RESISTANT ENZYME IRT-2 DERIVED FROM TEM-2 BETA-LACTAMASE PRODUCED BY PROTEUS-MIRABILIS STRAINS, Journal of antimicrobial chemotherapy, 38(2), 1996, pp. 183-191
Citations number
16
Categorie Soggetti
Microbiology,"Pharmacology & Pharmacy","Infectious Diseases
Journal title
Journal of antimicrobial chemotherapy → ACNP
ISSN journal
03057453
Volume
38
Issue
2
Year of publication
1996
Pages
183 - 191
Database
ISI
SICI code
0305-7453(1996)38:2<183:COAIEI>2.0.ZU;2-D
Abstract
Ten clinical isolates of Proteus mirabilis were found to produce an in hibitor-resistant TEM beta-lactamase (IRT) in association with a TEM-1 enzyme. The IRT enzyme was derived from TEM-2. The bla(IRT) gene diff ers from bla(TEM-2) gene by one point mutation which leads to the amin o-acid substitution Arg --> Ser at position 244, as observed for the o riginal IRT-2 enzyme derived from TEM-1 reported in Escherichia coli. This is the first report of an IRT beta-lactamase derived from TEM-2.