THE IN-VITRO ACTIVITY OF TROVAFLOXACIN AND 9 OTHER ANTIMICROBIALS AGAINST 413 ANAEROBIC-BACTERIA

The in-vitro activity of trovafloxacin and nine other antimicrobials w as determined for 413 non copy anaerobic clinical isolates. Trovafloxa cin was the most active quinolone tested with an MIC(90) of 0.5 mg/L a gainst Gram-positive cocci (n = 75); MIC(90) of 4 mg/L against Gram-po sitive bacilli (n = 151); MIC(90) of 0.5 mg/L for Gram-negative cocci (n = 12) and MIC(90) of 1 mg/L for Gram-negative bacilli (n = 175). Ov erall the MIC(90) of trovafloxacin was 1 mg/L which was equivalent to co-amoxiclav and one dilution higher than that of imipenem. The other seven comparators, including clindamycin and metronidazole, had higher MIC(90) values than trovafloxacin. Trovafloxacin is likely to have cl inically useful activity against anaerobes from human infection.