PROGNOSTIC POTENTIAL OF CYTOKINES, NITRATES, AND APACHE-II SCORE IN SEPSIS

The prognostic potentials of physiological ([Acute Physiologic and Chr onic Health Evaluation] APACHE II score) and biochemical (Interleukin 6 [IL-6], Interleukin 6 soluble receptor [IL-6sR], and Interleukin 2 r eceptor [IL-2R], nitrates) measures were evaluated in sepsis. The APAC HE II scores were calculated, and concentrations of the biochemical ma rkers were measured, based upon information rind samples obtained from 68 septic patients at time of diagnosis. Outcome (survival/nonsurviva l) was determined at the end of the hospital stay associated with the septic episode. Statistically significant differences between survivor s (S) and non-survivors (non-S) were found for APACHE II (p < 0.0001), IL-6 (p < 0.005), IL-6sR (p < 0.05), IL-2R (p < 0.02). No significant differences were found for nitrates. None of the markers could serve individually as an effective prognostic indicator. However, those mark ers demonstrating a significant difference between survivors and non-s urvivors may be able to contribute to a multi-parameter prognostic mod el.