W. Aung et al., DIFFUSE LARGE-CELL LYMPHOMA OF B-CELL TYPE ASSOCIATED WITH REACTIVE HEMOPHAGOCYTOSIS, Annals of clinical and laboratory science, 26(5), 1996, pp. 433-436
Some lymphomas, virtually all phenotypically of the T-cell type, have
been associated with the phenomenon of hemophagocytosis. Only two B-ce
ll lymphomas, one T-cell-rich and the other an angiocentric lymphoma,
have been observed to exhibit this phenomenon. A case is reported of a
diffuse large cell lymphoma of the B-cell type associated with reacti
ve hemophagocytosis. Cytokines or other humoral factors produced by th
e lymphoma are a possible cause, and their effect is probably systemic
. There is some evidence suggesting correlation of hemophagocytosis wi
th tumor aggressiveness.