SYNTHESIS AND ANTIMALARIAL ACTIVITY OF NEW 4,6-DIALKOXY-PYRIDO[3,2-G]QUINOLINE AND 4,6-BIS(ALKYLTHIO)PYRIDO[3,2-G]QUINOLINE DERIVATIVES

Authors
MATIAS C MAHAMOUD A BARBE J PRADINES B DOURY JC
Citation
C. Matias et al., SYNTHESIS AND ANTIMALARIAL ACTIVITY OF NEW 4,6-DIALKOXY-PYRIDO[3,2-G]QUINOLINE AND 4,6-BIS(ALKYLTHIO)PYRIDO[3,2-G]QUINOLINE DERIVATIVES, Heterocycles, 43(8), 1996, pp. 1621-1632
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Heterocycles → ACNP
ISSN journal
03855414
Volume
43
Issue
8
Year of publication
1996
Pages
1621 - 1632
Database
ISI
SICI code
0385-5414(1996)43:8<1621:SAAAON>2.0.ZU;2-8
Abstract
A set of 4,6-dialkoxy- and 4,6-bis(alkylthio)pyrido[3,2-g]quinoline de rivatives was prepared from 2,8,10-trimethylpyrido[3,2-g]quinoline-4,6 -dione as starting material. The latter was synthesized in a simple an d convenient two step procedure. These compounds were tested in vitro on chloroquinosusceptible and chloroquinoresistant strains of Plasmodi um falciparum. Two of them possess a 50% inhibitory concentration (IC5 0) lower than 100 nM against both strains.