EFFECT OF THE NEW ANTIALLERGIC AGENT OLOPATADINE ON EEG SPECTRAL POWERS IN CONSCIOUS RATS

The central effect of olopatadine (((Z)-11-[3-(dimethylamino)propylide ne)-6, 11-dihydrodibenz[b,e]oxepin-2-acetic acid hydrochloride, CAS 14 0462-76-6, KW-4679) was studied in comparison with those of ketotifen and doxepin using spontaneous EEG and EEG spectral powers in conscious rats. Both ketotifen (20 mg/kg p.o.) and doxepin (20 mg/kg p.o.) caus ed drowsy patterns in spontaneous EEG characterized by slow waves of h igh amplitude at the frontal cortex, occipital cortex and amygdala, an d by disappearance of the regularity in theta waves recorded from the hippocampus. In EEG spectral powers, both drugs caused a significant i ncrease in the power densities of the delta band recorded from the fro ntal cortex, occipital cortex and amygdala. On the contrary, no visibl e changes were elicited by the treatment with olopatadine (20 mg/kg p. o.) in both spontaneous EEG and EEG spectral powers recorded from the frontal cortex, occipital cortex, hippocampus and amygdala. These resu lts indicate that olopatadine provides no remarkable effect on the cen tral nervous system.